Pasteurized process cheese spread is made in much the same manner as pasteurized process cheese food, but generally contains higher moisture, and the milkfat content is usually lower. A stabilizer is used in this product to prevent separation of ingredients. It is normally more spreadable than cheese food. Cheese spread also may contain pimentos, fruits, vegetables or meats, or may have a smoked flavor.

The flavor of pasteurized process cheese spread depends largely on the flavor of the cheese used and may be modified by added flavorings. Some available varieties are pasteurized process American cheese spread, pasteurized process pimento cheese spread, pasteurized process pineapple cheese spread, and pasteurized process Blue cheese spread. Spreads are packaged in jars and loaves. They are convenient for use as snacks, in stuffing celery stalks, in deviled eggs, and as an ingredient in noodle casseroles, meatballs, hot vegetables, sandwiches, sauces, and dressings.